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MD in Gynecology Reviews the Top 5 Supplements to Tackle Menopausal Weight at Its Root to Lose and Keep It Off for Good

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My name is Dr. Elizabeth Levin. I am a board-certified gynecologist. And during the 30+ years of my medical practice, I noticed a worrying pattern.

Once you enter menopause, losing weight becomes nearly impossible.

And recent estimates by reputable institutions like Harvard should send chills down your spine.1,2

Because 2 out of 3 menopausal women gain weight. Meanwhile, 43% become obese during this life stage.

That’s without changing anything in their diet or lifestyle.

Or even worse, despite sweating for hours and meticulously counting calories.

That’s why I want to talk about the following three things:

  • What is the real root cause of unexplained weight gain during menopause
  • Why diet, exercise, and even HRT don’t work during this life stage
  • Which 5 supplements can tackle the root cause of menopausal weight

Also, I will explain which one (and why) of these 5 supplements is my preferred choice. So, without further ado, let’s dive in.

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So what exactly causes unexplained weight gain during menopause?

Contrary to common belief, it’s not estrogen or progesterone. Instead, it’s another hormone that also fluctuates during menopause.

Which most of my colleagues still overlook, unfortunately.

When it’s exactly what forces a woman’s body to accumulate and retain fat. Especially around the stomach.3

See, scientists from the University of Washington examined middle-aged women for 15 years.4
After 5,218 observations, they clearly saw one common thing between them all. Their cortisol levels soared during the transition to menopause.

When cortisol levels go haywire? I have seen many times what exactly happens after that during my medical practice:

  • Elevated cortisol triggers a “fight or flight” response and raises blood sugar5
  • All that blood sugar gets stored as fat since there’s no real threat
  • Your body starts pumping out insulin to prevent that
  • This causes insulin resistance where cells can’t take up energy efficiently

To put it simply, your body perceives a lack of energy and triggers irresistible cravings. And at the exact same time, it stores excess blood sugar as fat.

That’s why losing menopausal weight and keeping it off feels almost impossible.

Here’s why typical ways to lose weight make everything worse during menopause

In short, it’s because not only do they not address the real cause of menopausal weight. But they actually further increase cortisol.

Take weight loss diets, for example.

As you already know, cortisol raises blood sugar, which is then stored as fat. So you gain weight even without a calorie surplus.

What do most women then do?

They further reduce their calorie intake. But scientists from the universities of Minnesota and California found that to increase cortisol.6

In other words, strict diets can make you gain even more weight.

Which is why you may try to exercise more.

But the problem is that the University of North Carolina found intense exercise to increase cortisol by over 83%!7

This explains why diet and exercise can make you gain even more weight.

Top 5 supplements to reduce cortisol and get rid of menopausal weight for good

Now, before diving into those 5 supplements, I want to briefly discuss HRT. Because indeed, it helps relieve some of the menopause symptoms.

Including hot flashes, night sweats, and mood swings.

However, reputable institutions like the University of Chicago Medicine say that HRT won’t help you lose weight.8

That’s because this type of treatment supports declining estrogen.

But it does nothing to lower elevated levels of cortisol. When in fact, it’s the only way to lose menopausal weight.

Below are the top 5 supplements my patients and I found to do exactly that.

Serinisol™

Here’s what I like about Serinisol. Every serving contains 110 mg of Phosphatidylserine. This unique compound was found to lower cortisol by 25% in just 10 days.9

However, the dose used in that study was 8 times higher.

Considering that, you would have to buy 8 bottles instead of one, paying around $440 every month. This is neither affordable nor sustainable in the long run.

Verdict: Contains a powerful cortisol-lowering compound, but at a very low dose.

FLO Women’s Endocrine Superfood Powder

The next one on my list is FLO. This is a sophisticated supplement that contains various ingredients. But let’s talk only about those that lower cortisol.

FLO contains three of them. Rhodiola rosea, Maca root extract, and L-Theanine.

What’s interesting about L-Theanine is that it was found to lower cortisol by a stunning 42.4%. However, this effect doesn’t last and is only short-term.10

Verdict: Great for overall hormonal balance, but not the best option for lowering cortisol.

Live Conscious Zenwell

Here’s what makes Zenwell better than the previous supplement. In addition to L-Theanine, it also has Ashwagandha root extract.

Every Zenwell serving contains 600 mg of this compound.

The exact same amount that subjects in a 2023 study took for 60 days. And they lowered their cortisol levels by almost 28%.11

Verdict: Contains a clinically proven dose of the compound that lowers cortisol.

Happy Mammoth Hormone Harmony

The fourth supplement on my list is even better. It’s because Hormone Harmony has Ashwagandha and three more compounds that help lower cortisol.

Maca root extract, Rhodiola rosea, and Chamomile flower extract. And nine other ingredients that don’t affect cortisol. But they support the overall hormonal balance.

Verdict: Has a good potential to lower cortisol, but not the greatest of these 5 supplements.

Bioma

At the top of my list is Bioma. And there’s a good reason why. It’s because it contains ingredients I haven’t found in any of the previous four supplements.

First, it has three Bifidobacterium strains (B. lactis, B. longum, and B. breve). These “good” bacteria metabolize estrogen, which drops by 90% during menopause. But most importantly, Japanese scientists found them to be the only probiotic strains that lower cortisol.12,13,14

Second, it contains prebiotic xylooligosaccharides (XOS). Not only do they selectively feed Bifidobacterium. But scientists from the University of Oxford also found XOS to lower cortisol by 30% in just 3 weeks. When combined with probiotics? That number increased to 39%!15,16,17

Third, Bioma has postbiotic Tributyrin. This rare ingredient creates a favorable gut environment for Bifidobacterium and XOS for their maximum cortisol-lowering effect.18

And fourth, Bioma uses delayed-release capsules. This way, all these ingredients survive stomach acid and reach the gut intact. Which is an issue with other similar supplements.19

Verdict: Has ingredients that multiple studies found to have the greatest cortisol-lowering effect in the shortest time, plus it costs less than $1 a day.

Final word and a quick recap of this review

On the final note of this review, I want to say that my patients and I have tried dozens of different supplements over the years. And these five are the ones that actually work.

But Bioma consistently delivers the best results.

Here’s a quick recap of why it’s my #1 choice when it comes to lowering cortisol and losing menopausal weight:

  • Xylooligosaccharides were found to lower cortisol by 30% in just 3 weeks
  • 9B CFUs of probiotics that increase this number to 39% when combined
  • Tributyrin creates a favorable gut environment for these ingredients
  • Delayed-release capsules deliver them intact for maximum effect
  • Manufactured in an FDA-approved and GMP-certified facility

Plus, Bioma costs less than $1 a day, which makes it one of the best deals available today for any woman who wants to lose menopausal weight and keep it off for good.

Take advantage of this limited-time offer and try Bioma with 60% discount, free shipping, and a money-back guarantee!

IMPORTANT UPDATE

Since this article was published on Health Insider, Bioma has gained tremendous attention and interest. The company has reached out to our editorial team to inform us that, for a limited time, they are offering our readers an exclusive 60% discount on Bioma. Plus, every order comes with free shipping, three gifts, and a money-back guarantee.

– JanR58
13 May, 2025 at 1:16 pm

Been struggling with belly fat for 3 yrs since menopause hit, despite daily walks and cutting carbs. Doc just says “it’s normal” 🙄 Never mentioned cortisol! Might give Bioma a try… Anyone tried it yet? Thx!

– Linda
12 May, 2025 at 9:16 am

I’ve gained 37 pounds since menopause started and NOTHING has worked! My daughter sent me this article yesterday and I ordered right away. On fixed income so the discount helped. Just want to feel good in my own body again! Will give it the 3 months they recommend. Fingers crossed ladies! 🙏

– marybeth52
18 Apr, 2025 at 10:22 am

Ladies I’m on my 2nd bottle of Bioma and down 14 pounds!!! Tried EVERYTHING for 3 years after menopause – keto, IF, even those awful shakes. Nothing worked til this. Worth every penny! ❤️

 

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